Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 28, 2026Journal of Clinical MedicineOpen Access

Sentinel Lymph Node Biopsy for Early-Stage Oral Cavity Cancer: Analysis of Diagnostic Accuracy and False-Negative Cases

View Full Paper
Ask AI
Bookmark
Share

Authors

RLR. Lozano-RosadoHospital Universitario Virgen del RocíoADAlvaro De-Bonilla-DamiaInstituto de Biomedicina de SevillaGMGuiomar Martin-LozanoHospital Universitario Virgen del Rocío

Discussion

Loading...

Member takes

Implication

This retrospective analysis evaluates SLNB performance in early-stage OCSCC, suggesting implications for patient management.

Key Points

  • This study aims to assess the accuracy of sentinel lymph node biopsy in early-stage oral cavity squamous cell carcinoma and identify factors leading to false-negative results.
  • Conducted a retrospective cohort study on 220 patients with early-stage OCSCC.
  • Utilized preoperative lymphatic mapping with 99mTc-nanocolloid and SPECT/CT.
  • Applied an ultrastaging protocol with serial sectioning and immunohistochemistry on SLNs.
  • Analyzed diagnostic accuracy, survival outcomes, and clinicopathological predictors of false negatives.
  • SLN identification rate was 99.1% with metastatic involvement found in 22.3% of patients.
  • Sensitivity of SLNB was 81.7% and negative predictive value was 93.6%.
  • Depth of invasion and maximum tumour dimension were significant predictors of diagnostic failure.
  • Five-year overall survival was significantly higher in patients with negative SLNs (82% vs. 61%).

Cite This Study

Lozano-Rosado et al. (2026) studied this question.

synapsesocial.com/papers/69c771688bbfbc51511e146ahttps://doi.org/10.3390/jcm15072545
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sentinel Lymph Node Biopsy (SLNB) for Early-Stage Head and Neck Squamous-Cell Carcinoma of the Tongue: Twenty Years of Experience at I.N.T. “G.Pascale”2024 · 15 citations
  2. 2Sentinel lymph node biopsy in early oral cavity tumors: Evaluation of the oncologic efficacy compared to elective neck dissection2025 · 3 citations
  3. 3Diagnostic accuracy and additional value of diffusion-weighted imaging for discrimination of malignant cervical lymph nodes in head and neck squamous cell carcinoma2009 · 143 citations
  4. 4Sentinel Node Biopsy for Oral and Oropharyngeal Squamous Cell Carcinoma of the Head and Neck2007 · 151 citations
  5. 5What is the role of sentinel lymph node biopsy in the management of oral cancer in 2020?2020 · 58 citations