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This study aims to investigate how hydrocortisone affects the antimicrobial activity of various drugs against Staphylococcus aureus.

March 28, 2026Journal of Inflammatory and Infectious MedicineOpen Access

Hydrocortisone Impairs the Activity of Antimicrobial Drugs against Clinical Isolates of Staphylococcus aureus

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This study aims to investigate how hydrocortisone affects the antimicrobial activity of various drugs against Staphylococcus aureus.
Conducted in vitro tests to assess hydrocortisone's interference with antimicrobial drugs
Performed minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests
Analyzed chemical interactions using chemoinformatics techniques such as NMR, GC-MS, and FTIR
Hydrocortisone elevated MIC and MBC of oxacillin
Hydrocortisone abrogated the activity of gentamicin and chloramphenicol
Findings suggest potential risks in using hydrocortisone with these antimicrobials in clinical settings

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In vitro tests show hydrocortisone reduces effectiveness of antimicrobial drugs against Staphylococcus aureus, suggesting treatment risks.

Silva et al. (2026) studied this question.

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In vitro tests show hydrocortisone reduces effectiveness of antimicrobial drugs against Staphylococcus aureus, suggesting treatment risks.