Key result
Hydrocortisone infusion suppressed muscle sympathetic nerve activity burst number by 25%, compared to a 56% increase with placebo (P<0.05).
Why the study?
Does hydrocortisone reduce muscle sympathetic nerve activity and blood pressure in healthy subjects?
RCT (n=8)
Double-blind
Does hydrocortisone reduce muscle sympathetic nerve activity and blood pressure in healthy subjects?
Absolute Event Rate: -25% vs 56%
p-value: p=<0.05
Pharmacological doses of hydrocortisone acutely suppress muscle sympathetic nerve activity and decrease blood pressure in healthy humans, suggesting a mechanism for cardiovascular adaptation to stress.
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Supports glucocorticoid sympathoinhibition as stress adaptation mechanism; extends RCT evidence on autonomic regulation in humans.
Dodt et al. (2000) conducted an RCT in Healthy (n=8). Hydrocortisone vs. Placebo was evaluated on Muscle sympathetic nerve activity (MSA) burst number (p=<0.05). Hydrocortisone infusion suppressed muscle sympathetic nerve activity burst number by 25%, compared to a 56% increase with placebo (P<0.05).
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