Hydrocortisone-induced hypertension in humans: pressor responsiveness and sympathetic function.
Why the study?
Does oral hydrocortisone alter blood pressure, hemodynamics, and sympathetic function in healthy male volunteers?
Population
8 healthy male volunteers
Comparison
Oral hydrocortisone 200 mg/day for 1 week vs Baseline (before treatment)
Design
Cohort
Follow-up
1 week
Authors
Discussion
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Member takes
Implication
Short-term hydrocortisone may raise SBP via cardiac output in healthy men; leaves open effects and mechanisms in hypertensive patients.
Structured PICO
Does oral hydrocortisone alter blood pressure, hemodynamics, and sympathetic function in healthy male volunteers?
P
Population
8 healthy male volunteers
I
Intervention
Oral hydrocortisone 200 mg/day for 1 week
C
Comparator
Baseline (before treatment)
O
Outcome
Changes in blood pressure, cardiac output, total peripheral resistance, forearm vascular resistance, and norepinephrine spillover to plasmasurrogate
Oral hydrocortisone increases systolic blood pressure in healthy men primarily by increasing cardiac output and enhancing vascular sensitivity to norepinephrine, rather than increasing resting sympathetic nervous system activity.
Cite This Study
Sudhir et al. (1989) studied this question.