Why the study?
Does cortisol treatment increase muscle sympathetic vasomotor drive in healthy males?
Population
10 healthy male subjects on a fixed sodium diet (150 mmol/day)
Comparison
Cortisol 200 mg/day for 5 days vs Placebo for 5 days
Design
RCT, Randomized crossover, Double-blind
Follow-up
5 days per treatment period
Authors
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Cortisol suppresses muscle sympathetic activity despite raising blood pressure; challenges sympathetic mediation of cortisol-induced hypertension and redirects mechanistic research.
Does cortisol treatment increase muscle sympathetic vasomotor drive in healthy males?
Cortisol-induced hypertension is not mediated by increased muscle sympathetic vasomotor drive, as cortisol actually suppresses muscle sympathetic activity.
Vaughan G. Macefield (1998) studied this question.
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