Key result
Atenolol prevents the hydrocortisone-induced cardiac output rise but not the ~11 mm Hg systolic BP increase.
Why the study?
Does atenolol prevent the rise in blood pressure induced by hydrocortisone in normal volunteer men?
Population
n=6 normal volunteer men, aged 22 to 34 years
Comparison
Atenolol 50 mg orally 12 hourly on days 1 to 10… vs Placebo on days 1 to 10, plus hydrocortisone 50…
Design
RCT, random order
Follow-up
10 days per study period
Authors
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Atenolol does not prevent hydrocortisone-induced systolic BP rise; confirms cardiac output increase is not required and implicates peripheral resistance.
RCT (n=6)
Randomized crossover
Does atenolol prevent the rise in blood pressure induced by hydrocortisone in normal volunteer men?
p-value: p=<.01
The rise in cardiac output is not essential for hydrocortisone-induced hypertension, as blood pressure still rises when cardiac output is kept constant with atenolol.
Pirpiris et al. (1993) conducted an RCT in Healthy volunteers (n=6). Atenolol and hydrocortisone vs. Placebo and 50 mg cortisol 6 hourly was evaluated on Systolic blood pressure and cardiac output (p=<.01). Atenolol prevented the hydrocortisone-induced rise in cardiac output but did not prevent the rise in systolic blood pressure (which increased from 109 to 120 mm Hg, P<.01).
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