Key result
Prednisone decreased plasma norepinephrine levels and muscle sympathetic nerve activity compared to placebo in healthy subjects.
Why the study?
Does prednisone alter sympathetic activity and presynaptic alpha-2 adrenoceptor function in healthy subjects?
Population
15 healthy subjects
Comparison
Prednisone 20 mg orally daily each morning for 1… vs Placebo orally daily each morning for 1 week
Design
RCT, randomized, double-blind
Follow-up
1 week per treatment arm
Authors
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Short-term prednisone suppresses sympathetic activity in healthy humans; extends animal findings and supports trials in sympathetic hyperactivity states.
RCT (n=15)
Double-blind
randomized
Does prednisone alter sympathetic activity and presynaptic alpha-2 adrenoceptor function in healthy subjects?
Short-term prednisone administration decreases plasma norepinephrine levels and muscle sympathetic nerve activity in healthy humans, extending findings from animal models.
J. W. Lenders (1995) conducted an RCT in Healthy (n=15). Prednisone vs. Placebo was evaluated on Plasma levels of catechols and ACTH, and muscle sympathetic nerve activity (MSNA). Prednisone decreased plasma norepinephrine levels and muscle sympathetic nerve activity compared to placebo in healthy subjects.
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