Population
Conscious unrestrained Wistar-Kyoto rats
Design
Preclinical
Follow-up
7 days
Authors
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Animal data on cortisol-induced sympathoadrenal suppression and hypertension should not alter clinical care; leaves open mechanistic insights for future research.
Chronic cortisol treatment in rats suppresses basal sympathoadrenomedullary and hypothalamo-pituitary-adrenocortical activity while inducing hypertension, without impairing reflexive sympathetic activation.
Szemeredi et al. (1988) studied this question.
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