December 1, 1995Annals of the New York Academy of Sciences

Sympathoadrenal System in Stress

Q: What is the clinical evidence from this study?

Study design: Other. Population: Stress. Intervention: Glucocorticoid manipulation (adrenalectomy, cortisol treatment, hypophysectomy, ACTH) vs. Sham-operated, saline-treated, or intact rats. Primary outcome: Indices of catecholamine release, metabolism, synthesis, enzyme activities, and gene expression.

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Key result

Endogenous glucocorticoids suppress, whereas chronically elevated glucocorticoid levels stimulate, sympathoadrenal activity during stress in rats.

Population

Conscious rats (sham-operated, adrenalectomized, hypophysectomized, or intact)

Comparison

Adrenalectomy, cortisol treatment… vs Sham-operated, saline-treated, or unstressed…

Design

Preclinical

Authors

RKRichard KvětňanskýSlovak Academy of Sciences KPKarel PacákNovartis (Switzerland)KFKouki FukuharaYokohama National University

Discussion

Member takes

Implication

Should not change clinical practice; hypothesis-generating for glucocorticoid effects on sympathoadrenal stress responses.

Structured PICO

Population

Rats subjected to immobilization stress to examine glucocorticoid effects on sympathoadrenal activity.

Intervention

Adrenalectomy, cortisol treatment (acute or chronic for 7 days), hypophysectomy, ACTH pretreatment, and immobilization stress (IMO)

Comparator

Sham-operated, saline-treated, or unstressed control rats

Outcome

Indices of catecholamine release, metabolism, synthesis, biosynthetic enzyme activities (TH, PNMT), and gene expression (mRNA levels)surrogate

Endogenous glucocorticoids suppress, while chronically elevated glucocorticoids stimulate, sympathoadrenal activity during stress, with pituitary-adrenocortical factors playing an essential role in PNMT gene expression.

Cite This Study

Květňanský et al. (1995) studied Stress. Glucocorticoid manipulation (adrenalectomy, cortisol treatment, hypophysectomy, ACTH) vs. Sham-operated, saline-treated, or intact rats was evaluated on Indices of catecholamine release, metabolism, synthesis, enzyme activities, and gene expression. Endogenous glucocorticoids suppress, whereas chronically elevated glucocorticoid levels stimulate, sympathoadrenal activity during stress in rats.

synapsesocial.com/papers/6a1ff6b5c705fa157d0da4ff https://doi.org/10.1111/j.1749-6632.1995.tb44676.x

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Sympathoadrenal System in Stress

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sympathoadrenal System in Stress

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider