What question did this study set out to answer?

To assess the 3-year risk of type 2 diabetes mellitus in individuals with HIV-HCV co-infection after DAA initiation compared to those with HIV mono-infection.

March 28, 2026Open Access

Risk of type 2 diabetes mellitus after treatment with direct-acting antivirals for Hepatitis C virus in people with HIV.

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Authors

MCMathieu ChalouniHarvard University JTJessie Torgersen CRChristopher T. RentschUniversity of London

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Implication

Observational study compares type 2 diabetes risk in HIV-HCV co-infected individuals post-treatment, suggesting similar monitoring strategies as in HIV mono-infection.

Key Points

To assess the 3-year risk of type 2 diabetes mellitus in individuals with HIV-HCV co-infection after DAA initiation compared to those with HIV mono-infection.
Conducted an observational study using two cohort collaborations in Europe and North America.
Matched individuals with HIV-HCV co-infection to those with HIV mono-infection based on various factors.
Estimated the risk of type 2 diabetes post-DAA using inverse probability weighting.
Included 34,135 individuals with HIV-HCV co-infection and 68,720 with HIV mono-infection.
The 3-year T2DM risk difference was 0.8% in the no risk factor group, -0.4% in the 1-2 risk factors group, and -1.7% in the ≥3 risk factors group.
The estimated T2DM risk for those with HIV-HCV after DAA was similar to HIV mono-infection, though estimates were imprecise.

Cite This Study

Chalouni et al. (2026) studied this question.

synapsesocial.com/papers/69c771f08bbfbc51511e2191 https://doi.org/10.48620/96454

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Implication

Observational study compares type 2 diabetes risk in HIV-HCV co-infected individuals post-treatment, suggesting similar monitoring strategies as in HIV mono-infection.

Risk of type 2 diabetes mellitus after treatment with direct-acting antivirals for Hepatitis C virus in people with HIV.

Discussion

Member takes

Implication

Key Points

Cite This Study

Risk of type 2 diabetes mellitus after treatment with direct-acting antivirals for Hepatitis C virus in people with HIV.

Discussion

Member takes

Implication

Key Points

Cite This Study

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