What question did this study set out to answer?

The aim is to assess the three-year risk of type 2 diabetes mellitus in individuals with both HIV and HCV after starting direct-acting antivirals compared to those with HIV alone.

July 10, 2026Open Access

Risk of type 2 diabetes mellitus after treatment with direct-acting antivirals for hepatitis C virus in people with HIV

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Authors

MCMathieu ChalouniHarvard University JTJessie TorgersenEmory University CRChristopher T. RentschUniversity of London

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Implication

Observational study compares three-year risk of type 2 diabetes in HIV-HCV co-infection versus HIV mono-infection, suggesting similar monitoring is needed.

Key Points

The aim is to assess the three-year risk of type 2 diabetes mellitus in individuals with both HIV and HCV after starting direct-acting antivirals compared to those with HIV alone.
Matched individuals with HIV-HCV co-infection and HIV mono-infection based on cohort and diagnosis probability.
Estimated 3-year post-DAA T2DM risk using inverse probability weighting.
Analyzed subgroups based on the number of diabetes risk factors.
The 3-year risk difference of T2DM for HIV-HCV individuals post-DAA was 0.8% for no risk factors, -0.4% for 1-2 risk factors, and -1.7% for ≥3 risk factors.
Estimates indicated similar diabetes risk post-DAA treatment compared to those with HIV mono-infection, with wide confidence intervals.
Suggests diabetes monitoring and prevention for those treated with DAA should align with those who have HIV alone.

Cite This Study

Chalouni et al. (2026) studied this question.

synapsesocial.com/papers/6a508da76eeac72a437a102a https://doi.org/10.5167/uzh-434947

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Implication

Observational study compares three-year risk of type 2 diabetes in HIV-HCV co-infection versus HIV mono-infection, suggesting similar monitoring is needed.

Risk of type 2 diabetes mellitus after treatment with direct-acting antivirals for hepatitis C virus in people with HIV

Discussion

Member takes

Implication

Key Points

Cite This Study

Risk of type 2 diabetes mellitus after treatment with direct-acting antivirals for hepatitis C virus in people with HIV

Discussion

Member takes

Implication

Key Points

Cite This Study

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