Why the study?
Efficient efferocytosis is critical for tissue repair, and in the heart, inefficient clearance promotes an inflammatory environment that stresses nonregenerative cardiomyocytes.
Design
Review
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Should not yet change practice but identifies efferocytosis as therapeutic target post-MI; hypothesis-generating for regenerative research.
Efficient clearance of dying cells by efferocytosis is critical for organ development, inflammation resolution, and tissue repair. In the heart, the stakes of efficient clearance are high in that inefficient efferocytosis promotes an inflammatory environment that stresses the health of surrounding nonregenerative cardiomyocytes. Herein, we discuss the fundamental protagonists and therapeutic implications of efferocytosis within the myocardium during cardiac development, myocardial regeneration, and myocardial infarction.
Inui et al. (2026) studied this question.
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