Demonstrates efficient alkylation of enamides using photocatalysis in mild conditions, indicating broad applicability in organic synthesis.
Herein, we present a photocatalytic β-C(sp²)-H alkylation of enamides with easily accessible hydrocarbons under mild conditions. The utilization of aryl thianthrenium salt as a hydrogen-atom transfer (HAT) precursor enables the smooth generation of diverse carbon-centered radicals from chemical feedstocks containing hydridic or protic C-H bonds. Noteworthy features of this protocol encompass high step efficiency, good functional group compatibility, and excellent chemo-, regio-, and stereoselectivity. Mechanistic experiments and density functional theory (DFT) calculations support the involvement of an electron donor-acceptor (EDA) complex.
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Han et al. (2026) studied this question.
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