Organophotocatalytic approach synthesizes polycyclic sultones and sultams, implying a new pathway for efficient organic transformations.
An organophotocatalytic strategy for constructing polycyclic sultones and sultams has been developed. Utilizing sulfuryl chloride fluoride (FSO₂Cl) as a SO₂ radical cation synthon, a wide range of sultones and sultams were efficiently constructed from readily available propargyl alcohols and amines under mild conditions. This cascade transformation proceeds via radical fluorosulfonylation of alkynes, followed by radical ortho-cyclization and an intramolecular sulfur(VI) fluoride exchange (SuFEx) process.
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Liu et al. (2026) studied this question.
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