What question did this study set out to answer?

Synthesize established discoveries regarding the sequence, biosynthesis, and functional roles of the immunoglobulin J chain, while outlining future research directions.

April 1, 1985Annual Review of Immunology

The Coming of Age of the Immunoglobulin J Chain

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MKMarian Elliott KoshlandUniversity of California, Berkeley

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Implication

Review outlines the biosynthesis and regulatory roles of the immunoglobulin J chain in vertebrate lymphocytes, highlighting its essential function in antibody assembly and transport.

Key Points

Synthesize established discoveries regarding the sequence, biosynthesis, and functional roles of the immunoglobulin J chain, while outlining future research directions.
Narrative review evaluating sequence homology data, transcriptional regulation, and biosynthetic pathways of the J chain in mouse and human model systems.
Synthesis of experimental findings regarding J chain involvement in polymeric IgM and IgA assembly, secretion, and cytokine-mediated gene expression.
The J chain exhibits a highly conserved primary structure across vertebrates and is transcribed from a single unit regulated by chromatin structural changes.
Synthesis of J chain polypeptide is required for the assembly and secretion of pentamer IgM antibodies and supports the transcellular transport of both IgM and IgA.
Late-acting factors such as interleukin-2 amplify J-chain expression, establishing it as a model system for analyzing lymphocyte gene regulation.

Cite This Study

Marian Elliott Koshland (1985) studied this question.

synapsesocial.com/papers/69c7a0f3c69ebdbff4e77636 https://doi.org/10.1146/annurev.iy.03.040185.002233

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Implication

Review outlines the biosynthesis and regulatory roles of the immunoglobulin J chain in vertebrate lymphocytes, highlighting its essential function in antibody assembly and transport.

The Coming of Age of the Immunoglobulin J Chain

Discussion

Member takes

Implication

Key Points

Cite This Study

The Coming of Age of the Immunoglobulin J Chain

Discussion

Member takes

Implication

Key Points

Cite This Study

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