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March 29, 2026JACC Advances3 citationsOpen Access

AI-Enhanced Electrocardiogram for Detection of Occlusive Myocardial Infarction in High-Risk Non–ST-Segment Elevation Acute Coronary Syndrome

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PCPedro E.P. CarvalhoWBWill BelzerDPDaniel L. Pollmann

Key Result

AI-ECG improved rule-in accuracy for occlusive myocardial infarction in high-risk NSTE-ACS, but limited initial rule-out performance necessitates serial ECGs and clinical judgment.

Key Points

  • To evaluate the effectiveness of AI-enhanced electrocardiogram in detecting occlusive myocardial infarction in high-risk patients with NSTE-ACS.
  • Analyzed the accuracy of AI-ECG in identifying occlusive myocardial infarction.
  • Compared initial ECG results with serial ECG assessments.
  • Incorporated clinical judgment into the detection process.
  • AI-ECG improved accuracy for ruling in occlusive myocardial infarction.
  • Initial ECG alone had limited effectiveness for ruling out OMI.
  • Emphasized the necessity for serial ECGs and clinical assessment for better outcomes.

Structured PICO

Does AI-enhanced ECG improve the detection of occlusive myocardial infarction in patients with high-risk NSTE-ACS?

P
Population
Patients with high-risk non-ST-segment elevation acute coronary syndrome (NSTE-ACS)
I
Intervention
AI-enhanced electrocardiogram (AI-ECG)
O
Outcome
Rule-in accuracy for occlusive myocardial infarction (OMI)surrogate

AI-ECG improves rule-in accuracy for occlusive myocardial infarction in high-risk NSTE-ACS, aiding early identification for urgent invasive coronary angiography, though serial ECGs remain necessary for ruling out.

Limitations

  • Rule out performance from initial ECG alone was limited

Abstract

In high-risk NSTE-ACS, AI-ECG improved rule in accuracy for OMI, potentially enhancing early identification of patients requiring urgent ICA. However, rule out performance from initial ECG alone was limited, supporting the need for serial ECGs and clinical judgment.

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Cite This Study

Carvalho et al. (2026) studied this question. AI-ECG improved rule-in accuracy for occlusive myocardial infarction in high-risk NSTE-ACS, but limited initial rule-out performance necessitates serial ECGs and clinical judgment.

synapsesocial.com/papers/69c8c0b0de0f0f753b39b8a8https://doi.org/10.1016/j.jacadv.2026.102663
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