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March 1, 2026Thrombosis ResearchOpen Access

Cold exposure promotes thrombotic risk in ischemic stroke by activating the platelet cGAS-STING pathway

Yuchen Li Miaomiao Wei Yumeng Gu Jin Deng Xiaokun Guo Lin Wang Xin Li

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Key Points

To investigate the effects of cold exposure on thrombosis in ischemic stroke patients and the underlying biological mechanisms involved.
Conducted a cross-sectional study with 623 acute ischemic stroke patients comparing cold and non-cold season admissions.
Analyzed platelet and coagulation profiles through statistical models including Generalized Additive Models.
Performed parallel experiments in rats to observe the effects of cold on platelet function and activation of the cGAS-STING pathway.
Cold exposure led to significantly higher platelet count, mean platelet volume, and increased ADP-induced aggregation in patients.
In rats, cold exposure shortened bleeding time and increased platelet aggregation, indicating a prothrombotic state.
Activation of the cGAS-STING pathway was observed in platelets during cold exposure, and inhibition of this pathway reduced thrombotic effects.

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Implication

Cross-sectional analysis finds cold exposure increases thrombotic risk in ischemic stroke, suggesting new treatment targets.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69c8c115de0f0f753b39baba https://doi.org/10.1016/j.thromres.2026.109663

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