Platelets and acute cerebral infarction
Key result
Acute cerebral infarction was associated with lower in vivo platelet activity compared to atrial fibrillation controls (p<0.001 and p<0.01), with no difference in platelet reactivity.
Why the study?
Are platelet reactivity and activity altered in patients with acute cerebral infarction compared to patients with atrial fibrillation?
Population
130 subjects, comprising 72 patients with acute cerebral infarction and 58 atrial fibrillation controls.
Comparison
Measurement of platelet reactivity and activity… vs Atrial fibrillation patients subject to…
Design
Case-control
Authors
Discussion
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Member takes
Implication
May downplay platelet activity in AF-related stroke; leaves open prospective validation before reactivity testing informs therapy.
Study Design
Type
Case-Control (n=130)
Structured PICO
Are platelet reactivity and activity altered in patients with acute cerebral infarction compared to patients with atrial fibrillation?
P
Population
130 patients, including 72 with acute stroke and 58 atrial fibrillation controls, evaluated for platelet reactivity and activity.
E
Exposure
Measurement of platelet reactivity and activity using flow cytometry (TRAP-6 and ADP agonists) and ELISA (soluble P-selectin).
C
Comparator
Atrial fibrillation patients subject to electrical cardioversion.
O
Outcome
Platelet reactivity (platelet-bound P-selectin and fibrinogen after agonist provocation) and in vivo platelet activation (membrane-bound and soluble P-selectin without agonist stimulation).surrogate
Main Result
p-value: p=<0.001 and <0.01
Acute cerebral infarction is associated with lower in vivo platelet activity but similar platelet reactivity compared to atrial fibrillation, suggesting these specific platelet mechanisms may play a minor role in stroke pathophysiology.
Cite This Study
Järemo et al. (2012) conducted a case-control in Acute cerebral infarction (n=130). Acute cerebral infarction vs. Atrial fibrillation patients was evaluated on Platelet reactivity and in vivo platelet activity (surface attached and circulating P-selectin) (p=<0.001 and <0.01). Acute cerebral infarction was associated with lower in vivo platelet activity compared to atrial fibrillation controls (p<0.001 and p<0.01), with no difference in platelet reactivity.