Key result
Patients with acute non-cardioembolic ischemic stroke or TIA had significantly higher average baseline platelet p-selectin expression compared to healthy volunteers (10.29% vs 3.15%, p<0.000001).
Why the study?
Does antiplatelet therapy suppress baseline platelet p-selectin expression in patients with acute ischemic stroke?
Population
55 patients with acute ischemic stroke or TIA within 48 hours of symptom onset and 50 healthy volunteers…
Comparison
Antiplatelet therapy taken at the time of… vs Untreated patients and healthy volunteers.
Design
Cohort
Authors
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Elevated platelet p-selectin in acute non-cardioembolic stroke/TIA was not suppressed by prior antiplatelet therapy; leaves open its role as a therapeutic target.
Observational (n=105)
No
Does antiplatelet therapy suppress baseline platelet p-selectin expression in patients with acute ischemic stroke?
Absolute Event Rate: 10.2868% vs 3.146%
p-value: p=<0.000001
Platelet p-selectin expression is significantly elevated in the acute phase of ischemic stroke, but baseline expression is not significantly suppressed by prior antiplatelet therapy.
Kalmarova et al. (2018) conducted an observational in Acute ischemic stroke and Transient Ischemic Attack (TIA) (n=105). Acute ischemic stroke or TIA vs. Healthy volunteers was evaluated on Average platelet p-selectin expression (%) (p=<0.000001). Patients with acute non-cardioembolic ischemic stroke or TIA had significantly higher average baseline platelet p-selectin expression compared to healthy volunteers (10.29% vs 3.15%, p<0.000001).
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