Key result
Platelet CD63 and P-selectin expression remained high up to 90 days after atherosclerotic ischemic stroke, despite significantly decreased platelet aggregability after 72 hours.
Observational (n=29)
Platelet hyperactivation persists for at least 90 days after an atherosclerotic ischemic stroke, indicating a prolonged prothrombotic state.
Platelet activation is an important process in the pathogenesis of atherothrombosis. However, the serial changes of platelet activation in atherosclerotic ischemic stroke have not been determined. In this study, we measured serially platelet expression of CD63 and P-selectin and platelet aggregability to ADP and collagen. Measurements were made 24 and 72 h and 7 and 90 days after the ischemic event in 29 patients with atherosclerotic ischemic stroke. Platelet aggregability was significantly decreased after 72 h compared to that at 24 h of stroke onset. However, platelet CD63 and P-selectin expression remained high even 90 days after the events. These findings suggest that platelet hyperactivation in atherosclerotic ischemic stroke may be sustained for a considerable period.
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Cha et al. (2004) conducted an observational in Atherosclerotic ischemic stroke (n=29). Atherosclerotic ischemic stroke vs. Serial measurements at 24 h, 72 h, 7 days, and 90 days was evaluated on Platelet expression of CD63 and P-selectin and platelet aggregability to ADP and collagen. Platelet CD63 and P-selectin expression remained high up to 90 days after atherosclerotic ischemic stroke, despite significantly decreased platelet aggregability after 72 hours.
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