Key result
Female patients with acute cerebral infarction demonstrated significantly lower platelet reactivity to ADP (23% vs 32%, p=0.038) and TRAP-6 (35% vs 52%, p=0.016) compared to male patients.
Why the study?
Do female and male stroke sufferers differ regarding platelet reactivity?
Cross-Sectional (n=73)
No
Do female and male stroke sufferers differ regarding platelet reactivity?
Women suffering acute cerebral infarction have higher platelet counts but less reactive platelets compared to men, suggesting a potential need to individualize platelet inhibition by gender.
Answers are grounded in this paper and cite their sources.
Sex differences in post-stroke platelet parameters should not yet guide therapy; leaves open their impact on outcomes or individualized treatment.
OBJECTIVE: Platelets may well be significant in the pathogenesis of cerebral infarction. Platelets vary substantially according to gender. The scope of our current work is to establish if female and male stroke sufferers differ regarding platelet reactivity. PATIENTS AND METHODS: 73 Consecutive individuals stricken by acute ischemic cerebral infarction (31 females, 42 males) participated. All stroke subtypes were included. Platelet counts was determined electronically. Platelet reactivity i.e. the presence of surface-bound fibrinogen following provocation was analyzed with a flow cytometer. ADP (1.7 μmol/L) and a thrombin receptor agonist (TRAP-6) (57 μmol/L) were the agonists used. RESULTS: Female stroke sufferers had higher platelet counts (p = 0.013) but their platelets were less reactive. The p values were (p = 0.038) and (p = 0.016) for ADP and TRAP-6, respectively. CONCLUSION: The current study demonstrates that women suffering acute cerebral infarction have less reactive platelets. It is concluded that gender affects platelets. Our study indicates that it may be beneficial to individualize platelet inhibition of stroke sufferers according to gender.
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Järemo et al. (2015) conducted a cross-sectional in Acute ischemic cerebral infarction (n=73). Female gender vs. Male gender was evaluated on Platelet reactivity (platelet-bound fibrinogen after ADP 1.7 μmol/L provocation) (p=0.038). Female patients with acute cerebral infarction demonstrated significantly lower platelet reactivity to ADP (23% vs 32%, p=0.038) and TRAP-6 (35% vs 52%, p=0.016) compared to male patients.
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