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March 29, 2026PLoS ONEOpen Access

STING pathway contributes to Steroid-Hyporesponsive Lung Inflammation in DSS-induced colitis mice model

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Authors

MEMariam Wed EladhamNSNarjes Saheb Sharif-AskariBMBushra MdkhanaUniversity of Sharjah

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Implication

Evaluates STING pathway involvement in lung inflammation during colitis, suggesting new treatment insights.

Key Points

  • This research aims to explore the role of the STING pathway in lung inflammation related to colitis.
  • Utilized a dextran sulfate sodium (DSS) murine model of colitis to induce lung inflammation.
  • Examined the effect of a STING inhibitor on steroid response, focusing on the glucocorticoid receptor ratio.
  • Assessed inflammatory cell infiltration and cytokine levels in lung tissues.
  • DSS model resulted in increased lung inflammation and inflammatory cell infiltration.
  • Observed elevated levels of IL-17, IFN-γ, and bacterial DNA in lung tissues.
  • Inhibition of STING improved steroid sensitivity significantly compared to standard dexamethasone treatment.

Cite This Study

Eladham et al. (2026) studied this question.

synapsesocial.com/papers/69c8c277de0f0f753b39cc68https://doi.org/10.1371/journal.pone.0344511
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stimulator of interferon genes (STING) activation exacerbates experimental colitis in mice2019 · 108 citations
  2. 2DIFFERENTIAL STING ACTIVATION IN DENDRITIC CELLS SHAPES DISTINCT CD4 T CELL RESPONSES AND OPPOSING COLITIS OUTCOMES2026
  3. 3P0124 cGAS-STING in Inflammatory Bowel Disease—and repression by SCFAs through a HDAC-mediated mechanism2026
  4. 4Poster Session I - A39 CHARACTERIZING THE ROLE OF STING IN THE INTESTINAL EPITHELIUM2026
  5. 5FMT rescues mice from DSS-induced colitis in a STING-dependent manner2024 · 28 citations