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January 24, 2026Inflammatory Bowel Diseases

Differential Sting Activation in Dendritic Cells Shapes Distinct Cd4 T Cell Responses and Opposing Colitis Outcomes

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Authors

WYWenjing YangTYTianming YuSYSuxia Yao

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Overview

Experimental model investigates STING activation effects on CD4 T cell polarization in colitis, revealing distinct outcomes.

Key Points

  • This research aims to understand how varying levels of STING activation influence CD4+ T cell responses and outcomes in colitis.
  • Utilized a murine dextran sulfate sodium (DSS) colitis model to evaluate STING activation.
  • Administered low and high doses of the STING agonist 2′3′-cGAMP.
  • Assessed cytokine production and T cell polarization in vitro and in vivo.
  • Examined dendritic cells as upstream regulators of T cell modulation in colitis.
  • Low-dose cGAMP improved colitis by increasing IL-10 and promoting regulatory T cell development.
  • High-dose cGAMP worsened colitis, increasing IFN-γ and reducing regulatory T cells.
  • Dendritic cells showed differential sensitivity to STING agonists, influencing CD4+ T cell cytokine production.
  • IL-27 production from dendritic cells was linked to IL-10 production in CD4+ T cells.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69746149bb9d90c67120b20ahttps://doi.org/10.1093/ibd/izag006.007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stimulator of interferon genes (STING) activation exacerbates experimental colitis in mice2019 · 107 citations
  2. 2P0124 cGAS-STING in Inflammatory Bowel Disease—and repression by SCFAs through a HDAC-mediated mechanism2026
  3. 3STING pathway contributes to Steroid-Hyporesponsive Lung Inflammation in DSS-induced colitis mice model2026 · 2 citations
  4. 4STING trafficking activates MAPK–CREB signaling to trigger regulatory T cell differentiation2024 · 32 citations
  5. 5Synergistic innate immune activation and anti-tumor immunity through combined STING and TLR4 stimulation2024 · 3 citations