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January 1, 2026Journal of Diabetes ResearchOpen Access

Secretory Acid Sphingomyelinase in Children and Adolescents With Type 1 Diabetes

Chiara Mameli Alice Bolchini Cristina Ferrigno Paulina Roux Biejat Alessandro Arcari Silvia Zecchini Alessandra Napoli Francesca Redaelli Maddalena Macedoni Agnese Petitti Gianvincenzo Zuccotti E. Clementi Cristiana Perrotta

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Key Points

The study aims to assess the activity of secretory acid sphingomyelinase (S-ASMase) in children and adolescents with type 1 diabetes (T1D).
Evaluated S-ASMase activity in pediatric patients with new-onset and established T1D.
Compared S-ASMase activity levels between new-onset and established T1D patients.
Analyzed correlations between S-ASMase activity, HbA1c, triglycerides, and HDL-C levels.
New-onset T1D patients exhibit significantly higher S-ASMase activity than established T1D patients.
Positive correlation found between S-ASMase activity and HbA1c levels.
Positive correlation found between S-ASMase activity and triglyceride levels.
Negative correlation observed between S-ASMase activity and HDL-C levels.

Implication

The study evaluates S-ASMase activity in pediatric type 1 diabetes, suggesting a role in disease progression.

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Cite This Study

Mameli et al. (2026) studied this question.

synapsesocial.com/papers/69c8c2fcde0f0f753b39d86b https://doi.org/10.1155/jdr/5569377

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