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March 29, 2026Journal of Microbiology and BiotechnologyOpen Access

Characterization and Transcriptomic Analysis of Antarctic Planococcus sp. Mutant with Enhanced Carotenoid Content

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Authors

HPHee-Sun ParkJCJung‐Kap Choi

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Overview

This analysis uncovers genetic changes boosting carotenoid production in a microbial strain, suggesting new biotechnological applications.

Key Points

  • This research aims to understand the genetic factors that enhance carotenoid production in Planococcus sp. PAMC21323.
  • Conducted random mutagenesis using ethyl methanesulfonate to create pigment-variant strains.
  • Selected carotenoid-overproducing mutant R07 through colony pigmentation screening.
  • Utilized HPLC analysis for pigment quantification.
  • Performed RNA-seq analysis comparing wild type and R07 for transcriptomic profiling.
  • Identified a novel gene cluster contributing to C30 carotenoid production.
  • Showed upregulation of MEP pathway genes in the mutant R07.
  • Demonstrated downregulation of competing terpenoid pathways, redirecting flux toward carotenoid biosynthesis.

Cite This Study

Park et al. (2026) studied this question.

synapsesocial.com/papers/69c8c34bde0f0f753b39dfe3https://doi.org/10.4014/jmb.2512.12033
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