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March 29, 2026Open Access

A Universal Attractor Topology Governs Vertebrate Sex Determination

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ZBzetta byte

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Overview

Analyzing sex determination mechanisms in vertebrates demonstrates a universal geometric framework, suggesting deeper biological connections.

Key Points

  • To explore how a unified dynamical framework explains vertebrate sex determination and other regulatory systems.
  • Utilized deterministic ordinary differential equation (ODE) models and global parameter sweeps
  • Performed stochastic Langevin simulations and ridge-based geometric analysis
  • Analyzed varying parameters to correlate with biological outcomes
  • Identified four dynamical regimes linked to sex determination and clinical phenotypes
  • Showed that varying Hill cooperativity and auto-activation strength aligns with differences in disorder cases
  • Revealed a predictive model for XY fate commitment timing based on SRY influence

Cite This Study

zetta byte (2026) studied this question.

synapsesocial.com/papers/69c8c384de0f0f753b39e575https://doi.org/10.5281/zenodo.19258309
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