Why the study?
Does catheter ablation reduce the composite end point of death from any cause or hospitalization for worsening heart failure compared to medical therapy in patients with atrial fibrillation and heart failure?
Does catheter ablation reduce the composite end point of death from any cause or hospitalization for worsening heart failure compared to medical therapy in patients with atrial fibrillation and heart failure?
Catheter ablation significantly reduces the composite of all-cause mortality or heart failure hospitalization compared to medical therapy in patients with atrial fibrillation and heart failure.
May support ablation in AF with HF; hypothesis-generating and requires randomized confirmation before changing practice.
Catheter ablation for atrial fibrillation in patients with heart failure was associated with a significantly lower rate of a composite end point of death from any cause or hospitalization for worsening heart failure than was medical therapy. (Funded by Biotronik; CASTLE-AF ClinicalTrials.gov number, NCT00643188 .).
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Marrouche et al. (2018) studied this question.
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