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This review summarizes the advancements in in-situ gels specifically for ophthalmic drug delivery.

March 30, 2026Current Pharmaceutical Design

Advances in in-situ Gels for Ophthalmic Drug Delivery: Formulation Aspects, Mechanisms of Drug Release, and Therapeutic Application

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This review summarizes the advancements in in-situ gels specifically for ophthalmic drug delivery.
Review of existing literature on in-situ gels and their applications in ophthalmology
Analysis of formulation parameters and mechanisms for drug release
Examination of clinical and preclinical data regarding their efficacy
In-situ gels improve controlled release and bioavailability compared to traditional eye drops
Specific systems like ion-activated gellan gum have shown clinical effectiveness
Novel formulations incorporating polymers and nanoparticles enhance patient tolerability and ocular penetration

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Implication

This review highlights therapeutic applications of in-situ gels for controlled drug release in glaucoma and dry eye disease, indicating enhanced ocular treatment options.

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Azmi et al. (2026) studied this question.

synapsesocial.com/papers/69c9c51bf8fdd13afe0bd11e https://doi.org/10.2174/0113816128426852260125075320

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Implication

This review highlights therapeutic applications of in-situ gels for controlled drug release in glaucoma and dry eye disease, indicating enhanced ocular treatment options.

Advances in in-situ Gels for Ophthalmic Drug Delivery: Formulation Aspects, Mechanisms of Drug Release, and Therapeutic Application

Key Points

Discussion

Implication

Cite This Study

Advances in in-situ Gels for Ophthalmic Drug Delivery: Formulation Aspects, Mechanisms of Drug Release, and Therapeutic Application

Key Points

Discussion

Implication

Cite This Study

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