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March 30, 2026Journal of Analytical Toxicology

Sample Validity Lessons Learned from Challenging Cases and Proposed Biomarkers for Synthetic Urine Detection

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Authors

SJSamantha JoubertCLCatherine LynchACAndrew Carter

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Overview

Toxicology labs demonstrate the importance of validity testing for urine samples, suggesting new biomarkers for detection.

Key Points

  • The aim is to evaluate sample validity testing methods for detecting synthetic urine and inauthentic specimens.
  • Case analysis of three critical incidents identifying inauthentic specimens and one false identification due to a medical condition.
  • Examination of synthetic urine samples in routine casework.
  • Utilization of various biomarkers, including urea, uric acid, GGT, and amylase, for validity testing.
  • Identification of synthetic urine through biomarkers like urea and uric acid in some samples.
  • Amylase and GGT were most effective in detecting synthetic urine, with none found in samples.
  • Highlighting the collective interpretation of validity measures for accurate results.

Cite This Study

Joubert et al. (2026) studied this question.

synapsesocial.com/papers/69c9c553f8fdd13afe0bd3f5https://doi.org/10.1093/jat/bkag022
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