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March 30, 2026Brain CommunicationsOpen Access

Enhancing spontaneous recovery after stroke: a randomized controlled trial

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Authors

WBWinston D. ByblowMSM. ShanksBSBenjamin Scrivener

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Overview

Randomized controlled trial shows no effect on recovery metrics in stroke patients, implying spontaneous recovery plays a significant role.

Key Points

  • To evaluate the impact of high-dose virtual therapy on upper limb recovery post-stroke in a randomized trial.
  • Phase IIa biomarker-guided trial
  • Participants randomized into virtual therapy or conventional therapy
  • Intensive upper limb therapy over 3 weeks, with 90 min of therapist time daily
  • No effect of treatment group for the primary endpoint
  • Spontaneous recovery observed in measures like FM-UE and ARAT
  • Therapy dose was limited by patient and clinician factors

Cite This Study

Byblow et al. (2026) studied this question.

synapsesocial.com/papers/69c9c5c5f8fdd13afe0bdd35https://doi.org/10.1093/braincomms/fcag057
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of fully-immersive virtual reality for paretic arm recovery in stroke rehabilitation2025 · 3 citations
  2. 2Feasibility and efficacy of virtual reality rehabilitation for upper extremity impairment in ischaemic stroke patients: an open-label, parallel-group, randomised controlled trial2026
  3. 3Efficacy of a new video observational training method (intensive visual simulation) for motor recovery in the upper limb in subacute stroke: a feasibility and proof-of-concept study2024 · 1 citations
  4. 4Effects of Immersive Virtual Reality-Based Movement Therapy on Upper ExtremityFunctions and Cognitive Functions in Stroke Patients2023
  5. 5Virtual reality combined with task-oriented circuit training for upper limb rehabilitation in subacute stroke patients: A randomized controlled trial2025 · 2 citations