What question did this study set out to answer?

The aim is to evaluate the association of uric acid and lactate dehydrogenase with severe maternal morbidity in preeclampsia.

Predictive value of uric acid and lactate dehydrogenase for maternal morbidity in preeclampsia: a retrospective case-control study

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This case-control study shows uric acid significantly predicts severe maternal morbidity in preeclampsia, suggesting a potential screening tool.

The aim is to evaluate the association of uric acid and lactate dehydrogenase with severe maternal morbidity in preeclampsia.
Retrospective case-control study design
Analyzed 200 preeclampsia cases and 200 healthy controls
Measured serum uric acid and lactate dehydrogenase levels
Adjudicated maternal morbidities using specific clinical criteria
Used multivariable logistic regression for analysis
Mean uric acid and lactate dehydrogenase levels significantly higher in preeclampsia (p < 0.001)
Uric acid predicted acute kidney injury with high odds (aOR 3.21)
Uric acid levels ≥ 8.0 mg/dL were 100% sensitive for seizures
Average lactate dehydrogenase ≥ 516.4 IU/L had high negative predictive value for pulmonary edema
No preeclampsia-related deaths were recorded

Emral et al. (2026) studied this question.

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This case-control study shows uric acid significantly predicts severe maternal morbidity in preeclampsia, suggesting a potential screening tool.