What question did this study set out to answer?

This research aims to evaluate the effectiveness of early pregnancy biomarkers in predicting gestational diabetes mellitus (GDM).

March 30, 2026Frontiers in EndocrinologyOpen Access

Early pregnancy biomarkers for gestational diabetes mellitus prediction: a systematic review and meta-analysis of routine laboratory, metabolic, and inflammatory markers

View Full Paper

Ask AI

Bookmark

Authors

WLWenhui LiNSF NCAR High Altitude Observatory SJShengjuan JiangQinghai No.3 People's Hospital HXHailin XieQinghai No.3 People's Hospital

Discussion

Member takes

Implication

Systematic review evaluates early pregnancy biomarkers’ accuracy for predicting gestational diabetes mellitus, suggesting moderate to high diagnostic performance with notable variability.

Key Points

This research aims to evaluate the effectiveness of early pregnancy biomarkers in predicting gestational diabetes mellitus (GDM).
Systematic review of studies from PubMed, Web of Science, Embase, and Cochrane Library.
Inclusion of prospective cohort, case-control, or cross-sectional studies assessing biomarkers for GDM.
Quality assessment performed using QUADAS-2 criteria.
Meta-analyses conducted for biomarkers evaluated in at least three studies.
Assessment of diagnostic accuracy through pooled sensitivity, specificity, diagnostic odds ratio, and AUROC.
Twelve studies with 75 to 41,786 participants were included in the review.
PAPP-A levels decreased in women who developed GDM, showing a trend (SMD -0.558).
Metabolomic markers C5 and C5:1 showed high discrimination for GDM prediction (AUROC 0.934).
Overall pooled sensitivity was 81.6% and specificity was 93.4%.
High heterogeneity across studies was noted (I²=94-97%).

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69ca1210883daed6ee094e72 https://doi.org/10.3389/fendo.2026.1749694

View Full Paper

Ask AI

Bookmark

Implication

Systematic review evaluates early pregnancy biomarkers’ accuracy for predicting gestational diabetes mellitus, suggesting moderate to high diagnostic performance with notable variability.

Early pregnancy biomarkers for gestational diabetes mellitus prediction: a systematic review and meta-analysis of routine laboratory, metabolic, and inflammatory markers

Discussion

Member takes

Implication

Key Points

Cite This Study

Early pregnancy biomarkers for gestational diabetes mellitus prediction: a systematic review and meta-analysis of routine laboratory, metabolic, and inflammatory markers

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider