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March 30, 2026Journal of Geriatric OncologyOpen Access

Real-world patterns of maintenance therapy after allogeneic transplant in older adults with acute myeloid leukemia: A Medicare cohort study

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Authors

VKVanessa E. KennedyABAlana BlockCYChristopher Young

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Overview

Retrospective cohort study identifies low FLT3-TKI maintenance adherence in older adults with AML, suggesting areas for improvement.

Key Points

  • The aim is to analyze real-world patterns of FLT3-TKI maintenance therapy after allogeneic transplant in older adults with acute myeloid leukemia.
  • Conducted a retrospective cohort study using Medicare claims data.
  • Included older adults (65+) with AML who underwent allogeneic transplant and initiated FLT3-TKI maintenance.
  • Assessed adherence using proportion of days covered and evaluated dose modifications descriptively.
  • Collected baseline demographics and health care resource utilization data.
  • Only 150 of 7403 eligible patients initiated FLT3-TKI maintenance, with 54.7% receiving gilteritinib.
  • Overall adherence was modest at a mean proportion of days covered of 47%.
  • Gilteritinib showed the highest adherence, with two-thirds of patients experiencing no dose changes.

Cite This Study

Kennedy et al. (2026) studied this question.

synapsesocial.com/papers/69ca1280883daed6ee094fa2https://doi.org/10.1016/j.jgo.2026.102959
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