What question did this study set out to answer?

To evaluate multidimensional biomarkers in bronchoalveolar lavage fluid for lung cancer diagnosis and prognosis.

March 31, 2026SHILAP Revista de lepidopterologíaOpen Access

Multidimensional biomarker profiling of bronchoalveolar lavage fluid for diagnostic and prognostic evaluation of lung cancer: a retrospective observational study

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To evaluate multidimensional biomarkers in bronchoalveolar lavage fluid for lung cancer diagnosis and prognosis.
Retrospective observational analysis of 100 patients, including 65 with lung cancer and 35 with benign diseases.
Biomarker concentrations in bronchoalveolar lavage fluid measured (CEA, CYFRA21-1, NSE, ProGRP, IL-6, IL-8, IL-10).
ctDNA mutation profiles and immune-cell subpopulations analyzed from bronchoalveolar lavage fluid.
Receiver operating characteristic analysis for diagnostic performance, and Kaplan-Meier methods for overall survival analysis.
Higher concentrations of certain tumor markers and cytokines in lung cancer patients compared to benign controls.
Significantly elevated IL-6/IL-10 ratio in lung cancer patients.
ctDNA detection in BALF was more frequent than in peripheral blood.
Advanced TNM stage, elevated IL-6/IL-10 ratio, and lower CD8+/Treg ratio were linked to poorer overall survival.

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Implication

Retrospective observational study evaluates bronchoalveolar lavage biomarkers for lung cancer diagnosis and prognosis, suggesting utility for liquid biopsy.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69cb63c9e6a8c024954b879f https://doi.org/10.3389/fmed.2026.1774382

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Implication

Retrospective observational study evaluates bronchoalveolar lavage biomarkers for lung cancer diagnosis and prognosis, suggesting utility for liquid biopsy.

Multidimensional biomarker profiling of bronchoalveolar lavage fluid for diagnostic and prognostic evaluation of lung cancer: a retrospective observational study

Key Points

Discussion

Implication

Cite This Study

Multidimensional biomarker profiling of bronchoalveolar lavage fluid for diagnostic and prognostic evaluation of lung cancer: a retrospective observational study

Key Points

Discussion

Implication

Cite This Study

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