March 31, 2026European Urology3 citationsOpen Access
Prospective Comparison of 64Copper 64CuSAR-bisPSMA vs 68Gallium68Ga PSMA-11 PET/CT for Biochemical Recurrence of Prostate Cancer Following Radical Prostatectomy (Co-PSMA Trial)
This research aims to compare the effectiveness of 64Cu-bisPSMA-PET/CT and 68Ga PSMA-11 PET/CT for detecting prostate cancer recurrence after surgery.
Conducted a prospective trial comparing two imaging techniques.
Focused on men with biochemical recurrence after radical prostatectomy.
Assessed the true positive detection rates for both imaging modalities.
64Cu-bisPSMA-PET/CT identified significantly more disease recurrences than 68Ga PSMA-PET/CT.
Management decisions were positively influenced by the results from 64Cu-bisPSMA-PET/CT.
High true positive rate for disease detection was achieved with 64Cu-bisPSMA.
Abstract
64Cu-bisPSMA-PET/CT identifies a higher number of disease recurrences than 68Ga PSMA-PET/CT with substantial management impact and a high RS true positive rate in men with BCR post RP.