Each 1-SD increase in baseline estimated glucose disposal rate was associated with a 51% lower risk of incident heart failure (HR 0.49) in patients with coronary heart disease.
Cohort (n=20,329)
Yes
Does a higher estimated glucose disposal rate (eGDR) predict a reduced risk of incident heart failure in patients with coronary heart disease?
eGDR is a strong, independent predictor of incident heart failure and all-cause mortality in patients with coronary heart disease, with predictive changes detectable up to 15 years prior to clinical diagnosis.
Effect estimate: HR 0.49 (95% CI 0.38-0.64)
eGDR is closely linked to HF risk in the CHD population and exhibits stronger predictive power than other IR indices. Notably, eGDR levels change up to 15 years before the occurrence of HF, suggesting that eGDR could serve as an early predictor for HF among CHD patients.
Xu et al. (Sat,) conducted a cohort in Coronary heart disease (n=20,329). Estimated glucose disposal rate (eGDR) vs. Lower eGDR levels / Other insulin resistance indices was evaluated on Incident heart failure (HR 0.49, 95% CI 0.38-0.64). Each 1-SD increase in baseline estimated glucose disposal rate was associated with a 51% lower risk of incident heart failure (HR 0.49) in patients with coronary heart disease.