What question did this study set out to answer?

This research aims to clarify the relationship between hormone replacement therapy (HRT) and cardiovascular risk in postmenopausal women.

Hormone Replacement Therapy and Cardiovascular Risk in Postmenopausal Women

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Review synthesizes evidence on HRT effects on cardiovascular risk in postmenopausal women, suggesting individualized therapy is key.

This research aims to clarify the relationship between hormone replacement therapy (HRT) and cardiovascular risk in postmenopausal women.
Reviewed major randomised trials, observational studies, and meta-analyses.
Evaluated the impact of timing and type of hormone therapy on cardiovascular outcomes.
Assessed the role of individualized therapy based on patient risk profiles.
Early initiation of HRT within ten years shows cardiovascular benefits.
Delayed initiation increases risks, including stroke and venous thromboembolism.
Transdermal and bioidentical hormones present a safer cardiovascular profile than oral synthetic preparations.

BLACKBURN et al. (2026) studied this question.

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