Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 31, 2026Anti-Cancer Agents in Medicinal Chemistry

Sulfonamides as Aromatase Inhibitors: Nimesulide Analogues, N-cyclic- and Aryl-Sulfonamides

View Full Paper
Ask AI
Bookmark
Share

Authors

CMCristina MaccalliniUniversity of Chieti-PescaraAAAlessandra AmmazzalorsoUniversity of Chieti-PescaraBFBarbara De FilippisUniversity of Chieti-Pescara

Discussion

Loading...

Member takes

Implication

This review discusses sulfonamide-based aromatase inhibitors and their enzyme interactions, emphasizing structural relationships.

Key Points

  • The review aims to analyze structure–activity relationships of nonsteroidal aromatase inhibitors with sulfonamide groups.
  • Literature review of existing sulfonamide-based aromatase inhibitors
  • Classification based on core scaffold: nimesulide analogues, N-cyclic sulfonamides, aryl-sulfonamides
  • Evaluation of biological results related to enzyme inhibition
  • Molecular modeling to assess interactions with active-site residues of aromatase.
  • Identified significant structure–activity relationships for sulfonamide-containing aromatase inhibitors.
  • Demonstrated effective enzyme inhibition through hydrogen bonding interactions.
  • Highlighted the importance of hydrophobic groups and aromatic rings in binding affinity.

Cite This Study

Maccallini et al. (2026) studied this question.

synapsesocial.com/papers/69cb6541e6a8c024954b9506https://doi.org/10.2174/0118715206416396251122063142
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Discovery and Evaluation of Novel Sulfonamide Derivatives Targeting Aromatase in ER+ Breast Cancer2025 · 3 citations
  2. 2Synthesis, Characterization, and In vitro and In Silico Studies of New Triazole Derivatives as Aromatase Inhibitors2024 · 1 citations
  3. 3Novel Aromatase Inhibitors by Structure-Guided Design2012 · 218 citations
  4. 4Molecular mechanisms of aromatase inhibition by new A, D-ring modified steroids2008 · 17 citations
  5. 5Ligand and Structure-Based Drug Design of Biphenyl 1,2,4-Triazole Derivatives as Dual Target Inhibitors of Aromatase and Steroidal Sulfatase as Anti-Breast Cancer Agents2026