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April 1, 2026Epigenetics ReportsOpen Access

The effects of methylphenidate and atomoxetine on epigenetic DNA modifiers in an in vitro model of human peripheral blood mononuclear cells

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Authors

KPKerda PulkUniversity of TartuGSG. SchotterUniversity of TartuKAKaili AnierUniversity of Tartu

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Implication

In vitro model demonstrates that MPH and ATX do not affect epigenetic DNA modifiers in PBMCs, implying no sensitization to cocaine.

Key Points

  • This research aims to investigate how methylphenidate and atomoxetine influence epigenetic DNA modifiers in PBMCs.
  • Used in vitro model of human peripheral blood mononuclear cells
  • Examined concentration-dependent effects of MPH and ATX
  • Assessed mRNA levels and enzymatic activity of DNMTs and TETs
  • Evaluated sensitivity of PBMCs to cocaine exposure after MPH or ATX exposure
  • Repeated MPH or ATX exposure did not affect mRNA levels of DNMTs or TETs
  • No change in enzymatic activity of DNMTs or TETs in PBMCs after exposure
  • Prior exposure to either drug did not sensitize PBMCs to cocaine treatment

Cite This Study

Pulk et al. (2026) studied this question.

synapsesocial.com/papers/69ccb55116edfba7beb8744fhttps://doi.org/10.1080/28361512.2026.2650336
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