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The study aimed to investigate the pathogenicity of Porcine Parainfluenza Virus 1 (PPIV1) in pigs and assess its effects on the respiratory system.

April 1, 2026PLoS PathogensOpen Access

Experimental inoculation of pigs with porcine parainfluenza virus 1 revealed pathological manifestations in the upper respiratory tract

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Experimental inoculation demonstrates pathological effects of Porcine Parainfluenza Virus 1 in pigs, indicating its role as a respiratory pathogen.

The study aimed to investigate the pathogenicity of Porcine Parainfluenza Virus 1 (PPIV1) in pigs and assess its effects on the respiratory system.
Pigs were inoculated with PPIV1, SOV RNA-positive material, or culture medium as controls.
Nasal swabs, tissue samples, and blood samples were collected for testing.
Four pigs inoculated with SOV were transferred to the PPIV1 group to study direct-contact transmission.
Pigs were euthanized at 4 and 14 days post inoculation (DPI) for necropsy and examination.
PPIV1 RNA shedding was observed from DPI 2 to 11, peaking between DPI 4 and 7.
Horizontal transmission of PPIV1 was confirmed in direct-contact pigs.
Chronic tracheitis developed in PPIV1-infected pigs, with erosive changes by 14 DPI.
Mild bronchointerstitial pneumonia was noted in three pigs at 14 DPI.
All PPIV1-inoculated pigs seroconverted by 14 DPI.

Agerlin et al. (2026) studied this question.

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Experimental inoculation demonstrates pathological effects of Porcine Parainfluenza Virus 1 in pigs, indicating its role as a respiratory pathogen.