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The research aims to identify novel allelic variations in the HLA-C gene, focusing on HLA-C*08:01:44.

April 1, 2026HLA

Discovery of the Novel HLA‐C*08:01:44 Allele in a Taiwanese Individual

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The research aims to identify novel allelic variations in the HLA-C gene, focusing on HLA-C*08:01:44.
Genetic sequencing to analyze nucleotide variations
Identification of specific codon substitutions
Comparison against known HLA-C alleles
Discovery of HLA-C*08:01:44 resulting from a nucleotide substitution at codon 105
Characterization of the novel allele highlights genetic diversity in the Taiwanese population

Genetic analysis reveals a new HLA-C allele in an individual, suggesting further genetic diversity.

One nucleotide substitution in codon 105 of HLA-C*08:01:01:01 results in a novel allele, HLA-C*08:01:44.

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Yang et al. (2026) studied this question.

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Genetic analysis reveals a new HLA-C allele in an individual, suggesting further genetic diversity.

One nucleotide substitution in codon 105 of HLA-C*08:01:01:01 results in a novel allele, HLA-C*08:01:44.