A Decade of NH-Transfer via Iodonitrene: A Journey of NH-Transfer from Sulfur and Nitrogen to Alkenes

The incorporation of nitrogen atoms in lead compounds can significantly alter their physicochemical properties so that efficient methodologies for their introduction are highly sought after. In the last decade, electrophilic NH-transfer via in situ generated intermediates from ammonia sources and hypervalent iodine reagents have attracted interest for their varied reactivity reaching from N-transfer to heteroatoms to core remodeling tactics. We herein describe the journey from the introduction of this tactic to its most recent application for the synthesis of NH-aziridines.1.Synthesis of NH-Aziridines5.Post-Finish Cool-Down: Mechanistic Insights and DebateConclusion