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April 1, 2026Биохимия / Biochemistry

Mitochondrial Lipid Peroxidation Initiates Rapid Accumulation of Lipofuscin in Cell Culture

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Authors

HHH. HeAPA. A. PanteleevaRSR. A. Simonyan

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Overview

Shows that mitochondrial lipid peroxidation accelerates lipofuscin accumulation in cultured cells, suggesting potential treatment avenues.

Key Points

  • The research focuses on understanding how mitochondrial lipid peroxidation influences lipofuscin accumulation in cells.
  • Used cystine transport inhibitor erastin and glutathione peroxidase-4 inhibitor RSL3 in cell cultures.
  • Applied antioxidant SkQ1 and redox mediator methylene blue to evaluate effects.
  • Monitored lipofuscin accumulation and reactive oxygen species generation in rat H9c2 cardiomyoblasts and human fibroblasts.
  • Rapid accumulation of lipofuscin occurs within 18 hours alongside increased lipid peroxidation.
  • Mitochondria-targeted antioxidants significantly blocked both lipid peroxidation and lipofuscin formation.
  • Isolated heart mitochondria showed lipofuscin accumulation influenced by iron ions and reactive oxygen species.

Cite This Study

He et al. (2025) studied this question.

synapsesocial.com/papers/69ccb6b416edfba7beb88763https://doi.org/10.7868/s3034529425120145
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exogenous Iron Induces Mitochondrial Lipid Peroxidation, Lipofuscin Accumulation, and Ferroptosis in H9c2 Cardiomyocytes2024 · 22 citations
  2. 2Age pigment lipofuscin causes oxidative stress, lysosomal dysfunction, and pyroptotic cell death2024 · 1 citations
  3. 3Mitochondrial lipid peroxidation is necessary but not sufficient for induction of ferroptosis2024 · 3 citations
  4. 4Cellular accumulation of lipofuscin in the heart: implications in health and disease2026
  5. 5Towards periodic whole-body lipofuscin removal2024