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April 1, 2026PLOS WaterOpen Access

Achieving sub-part per trillion trace level PFAS quantification in drinking water using an optimized fast flow solid-phase extraction and UPLC-MS/MS method

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Authors

DTDeepak TimalsinaBRBhargavi Srija RamisettyMWM. Wang

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Overview

Research develops a rapid method for quantifying PFAS in drinking water, indicating significant improvements in sensitivity and cost-effectiveness.

Key Points

  • This research aims to enhance the sensitivity and efficiency of PFAS detection in drinking water.
  • Developed an optimized fast flow solid-phase extraction method.
  • Investigated key sample preparation parameters affecting PFAS recovery.
  • Validated the method using blank and spiked tap water samples.
  • Achieved sub-ppt trace level quantification of PFAS compounds.
  • Reduced sample loading time significantly compared to conventional methods.
  • Maintained PFAS recovery for 38 out of 40 target compounds.

Cite This Study

Timalsina et al. (2026) studied this question.

synapsesocial.com/papers/69ccb6ce16edfba7beb888ffhttps://doi.org/10.1371/journal.pwat.0000501
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