What question did this study set out to answer?

This study aims to compare gut microbiome signatures between cirrhosis patients with and without hepatocellular carcinoma (HCC).

April 1, 2026Journal of Gastroenterology and Hepatology

Gut Microbiome Signatures Differ in Cirrhosis With and Without Hepatocellular Carcinoma in a Southeast Asian Cohort

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This study aims to compare gut microbiome signatures between cirrhosis patients with and without hepatocellular carcinoma (HCC).
Analyzed gut microbiome in a Thai cohort of patients with cirrhosis and HCC
Measured BCoAT expression levels
Assessed gut permeability and cytokine profiles
Patients with HCC showed distinct gut microbial changes compared to those without
Reduced BCoAT expression was linked with HCC presence
Increased gut permeability and cytokine alterations were observed in HCC patients

Implication

Cohort study reveals distinct microbial changes in cirrhosis with hepatocellular carcinoma, indicating implications for liver disease progression.

Abstract

Among the Thai cohort, HCC with cirrhosis was associated with distinct gut microbial changes, reduced BCoAT expression, increased gut permeability, and cytokine alterations, highlighting the contribution of gut dysbiosis and microbial by-products to liver disease progression.

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Cite This Study

Jinato et al. (2026) studied this question.

synapsesocial.com/papers/69ccb6fd16edfba7beb88c03 https://doi.org/10.1111/jgh.70358

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Implication

Cohort study reveals distinct microbial changes in cirrhosis with hepatocellular carcinoma, indicating implications for liver disease progression.

Gut Microbiome Signatures Differ in Cirrhosis With and Without Hepatocellular Carcinoma in a Southeast Asian Cohort

Key Points

Implication

Abstract

Discussion

Cite This Study

Gut Microbiome Signatures Differ in Cirrhosis With and Without Hepatocellular Carcinoma in a Southeast Asian Cohort

Key Points

Implication

Abstract

Discussion

Cite This Study

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