What question did this study set out to answer?

To identify specific gut microbiota profiles, intestinal permeability characteristics, and systemic inflammatory markers associated with hepatocellular carcinoma in patients with NAFLD-related cirrhosis.

April 17, 2018Hepatology

Hepatocellular Carcinoma Is Associated With Gut Microbiota Profile and Inflammation in Nonalcoholic Fatty Liver Disease

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Authors

FPFrancesca Romana PonzianiUniversità Cattolica del Sacro Cuore SBSherrie BhooriFondazione IRCCS Istituto Nazionale dei Tumori CCChiara CastelliUniversity of Rome Tor Vergata

Discussion

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Implication

Observational study reveals distinct gut microbiota shifts and heightened inflammation in NAFLD-cirrhosis patients with liver cancer, suggesting microbial involvement in hepatocarcinogenesis.

Key Points

To identify specific gut microbiota profiles, intestinal permeability characteristics, and systemic inflammatory markers associated with hepatocellular carcinoma in patients with NAFLD-related cirrhosis.
Enrolled a consecutive cohort of patients categorized into three groups: NAFLD-related cirrhosis with hepatocellular carcinoma (n=21), NAFLD-related cirrhosis without hepatocellular carcinoma (n=20), and healthy controls (n=20).
Evaluated gut microbiota composition, intestinal permeability, plasma inflammatory cytokines/chemokines, and circulating mononuclear cell activation, followed by correlation modeling.
Patients with hepatocellular carcinoma demonstrated significantly increased fecal calprotectin alongside elevated plasma levels of IL-8, IL-13, CCL3, CCL4, and CCL5 associated with activated circulating monocytes, while intestinal permeability did not differ between cirrhosis cohorts.
Cirrhosis patients overall exhibited elevated Enterobacteriaceae and Streptococcus and decreased Akkermansia, whereas the hepatocellular carcinoma group specifically showed increased Bacteroides and Ruminococcaceae along with reduced Bifidobacterium.
Akkermansia and Bifidobacterium were inversely correlated with fecal calprotectin, which directly correlated with multiple humoral and cellular markers of systemic inflammation.

Cite This Study

Ponziani et al. (2018) studied this question.

synapsesocial.com/papers/69da24f0ba6014a02e8360ef https://doi.org/10.1002/hep.30036

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Implication

Observational study reveals distinct gut microbiota shifts and heightened inflammation in NAFLD-cirrhosis patients with liver cancer, suggesting microbial involvement in hepatocarcinogenesis.

Hepatocellular Carcinoma Is Associated With Gut Microbiota Profile and Inflammation in Nonalcoholic Fatty Liver Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Hepatocellular Carcinoma Is Associated With Gut Microbiota Profile and Inflammation in Nonalcoholic Fatty Liver Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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