What question did this study set out to answer?

This meta-analysis aims to evaluate the effectiveness and safety of Thulium Fiber Laser versus Holmium Laser in ureteroscopic lithotripsy.

April 1, 2026MedicinaOpen Access

Thulium Fiber Laser Versus Holmium Laser for Ureteroscopic Lithotripsy: A Systematic Review and Meta-Analysis

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Meta-analysis compares thulium fiber laser and holmium laser efficacy in ureteroscopic lithotripsy, suggesting superior outcomes with TFL.

This meta-analysis aims to evaluate the effectiveness and safety of Thulium Fiber Laser versus Holmium Laser in ureteroscopic lithotripsy.
Conducted a systematic search across multiple databases following PRISMA guidelines.
Included randomized and non-randomized comparative studies on TFL and Ho:YAG laser.
Primary outcomes focused on stone-free rates and complication rates during and after procedures.
TFL group showed significantly higher stone-free rates than Ho:YAG group (OR = 1.57, p = 0.001).
In subgroup analysis, TFL was superior to standard Ho:YAG without pulse modulation (OR = 1.69, p = 0.01).
No significant differences in intraoperative (OR = 0.77, p = 0.52) or postoperative complication rates (OR = 1.02, p = 0.93) were found between the groups.

Ahn et al. (2026) studied this question.

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Meta-analysis compares thulium fiber laser and holmium laser efficacy in ureteroscopic lithotripsy, suggesting superior outcomes with TFL.