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April 1, 2026Infection and Drug ResistanceOpen Access

Genomic Characteristics of a Carbapenem-Resistant Escherichia coli Co-Carrying blaNDM-5 and mcr-1.1 from a Urinary Tract Infection in China

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Authors

JJJuan JinChildren's Hospital of Zhejiang UniversityLHLing HuangChildren's Hospital of Zhejiang UniversityDBDanni BaoNantong University

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Implication

Uncovers genomic traits of drug-resistant E. coli in urine, suggesting urgent public health actions.

Key Points

  • The study aims to analyze the genomic features of a multidrug-resistant E. coli strain co-harboring resistance genes.
  • Conducted antimicrobial susceptibility testing using broth microdilution assay.
  • Employed Clermont Typing platform for phylogenetic classification.
  • Utilized BacWGSTdb 2.0 for sequence typing and core genome analysis.
  • Identified resistance genes via SerotypeFinder, CHTyper, PlasmidFinder, and ResFinder databases.
  • E. coli strain SM107 showed resistance to nearly all antibiotics except nitrofurantoin.
  • Complete genome analysis revealed a single chromosome and six plasmids, assigned to sequence type ST1011.
  • The bla NDM-5 gene was found on a 119,850 bp IncI1-1-type plasmid, while mcr-1.1 was on a 111,450 bp IncI2-type plasmid.
  • cgMLST analysis highlighted the emergence of ST1011 strains harboring both colistin and carbapenem resistance genes.

Cite This Study

Jin et al. (2026) studied this question.

synapsesocial.com/papers/69ccb71716edfba7beb88ec9https://doi.org/10.2147/idr.s590642
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