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May 9, 2026Infection and Drug ResistanceOpen Access

Convergence of Carbapenem and Colistin Resistance in Intestinal Escherichia coli ST167/ST2659 Driven by IncX3 blaNDM-5 and IncI2-Associated Mcr-1.1 Mobility

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Authors

LBLianmin BaoWenzhou Medical UniversityTHTian HuZhejiang Chinese Medical UniversityQZQing ZhangWenzhou Medical University

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Implication

Randomized trial evaluates multi-plasmid resistance in Escherichia coli, suggesting significant implications for antibiotic spread.

Key Points

  • This research aims to understand the mechanisms behind multidrug-resistant Escherichia coli colonization and resistance gene transfer.
  • Analyzed two E. coli isolates positive for bla NDM-5 and mcr-1.1 from fecal samples.
  • Used antimicrobial susceptibility testing, short- and long-read sequencing, PFGE, and Southern blot for gene localization.
  • Conducted conjugation assays to assess plasmid transferability.
  • Both isolates exhibited resistance to colistin (MIC 4 mg/L) and carbapenems (L1771: imipenem 32 mg/L; L2386: imipenem 16 mg/L).
  • L1771 had a bla NDM-5 -carrying IncX3 plasmid; L2386 contained both IncX3 and IncI2 plasmids.
  • All plasmids were transferable via conjugation, indicating a strong potential for horizontal gene transfer.

Cite This Study

Bao et al. (2026) studied this question.

synapsesocial.com/papers/69fed17eb9154b0b82878e0bhttps://doi.org/10.2147/idr.s594479
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