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This research demonstrates carbonylation of unactivated alkyl chlorides, suggesting new synthetic routes in organic chemistry.
Unactivated alkyl chlorides are ideal but underutilized building blocks in carbonylation due to the high strength of C-Cl bonds and the limitations of existing transition-metal catalysis. Herein, we describe a Salen-cobalt-catalyzed carbonylative transformation of unactivated alkyl chlorides under mild conditions, enabled by the supernucleophilic Co(I) center that efficiently promotes SN2-type C-Cl activation. This system accommodates sterically hindered nucleophiles and proceeds through a well-supported radical-involved organocobalt catalytic cycle, providing a general platform for carbonylation of challenging alkyl chlorides.
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Xu et al. (2026) studied this question.
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